Animal model have been used extensively to study of experimental ulcerative colitis syndromes. Some compounds and chemical agents like acetic acid (AA), trinitrobenzene sulfonic acid (TNBS), iodoacetamide, indomethacin, oxazolone, dexran sodium sulphate (DSS) and peptidoglycan polysaccharide used for the induction of colitis. Induction of colitis by chemical/compounds is an easily inducible model of inflammatory bowel disease and the inflammatory phase bears some resemblance to acute human intestinal inflammation. Recent studies suggest that the search for the new agent (compounds/medicinal plants/herbs) and its mechanism for colitis continue in animal models. Despite the difference in anatomy, physiology, and nutritional factors between animal model systems and the human body, the fact remains that one or more of these model systems may reflect the same mechanism or etiologic agent which occurs in the human ulcerative colitis.
Loading....